Pd(OAc)₂-catalyzed dehydrogenative C–H activation: An expedient synthesis of uracil-annulated β-carbolinones

• Biplab Mondal,
• Somjit Hazra,
• Tarun K. Panda and
• Brindaban Roy

Beilstein J. Org. Chem. 2015, 11, 1360–1366, doi:10.3762/bjoc.11.146

• .11.146 Abstract An intramolecular dehydrogenative C–H activation enabled an efficient synthesis of an uracil-annulated β-carbolinone ring system. The reaction is simple, efficient and high yielding (85–92%). Keywords: β-carbolinones; cyclization; dehydrogenative C–H activation; Pd(OAc)2; uracil

• -carbolinones via a high yielding dehydrogenative C–H activation process. The key to the success of this reaction is the complementary electronic properties of the indole C3–H bond and the uracil C6–H bond. It is anticipated this efficient and atom economic approach can be emulated for the preparation of other

• dehydrogenative annulation of indole-carboxamides with alkynes etc [36]. The development of metal-catalyzed C–H activation reaction has revolutionized the way a synthetic chemist now approaches a traditional C–C bond disconnection [32][33][34][35][36][37][38][39][40][41][42][43][44]. Dehydrogenative C–H